You’ll probably be asked to stick to a short set time of between 20 and 30 minutes. Create a tight set of songs that showcases your music and creates some kind of momentum, and don’t play covers unless you’ve specifically cleared it with the venue. Some music venues aren’t legally set up for their bands to perform covers.
Far too many first-rate bands can’t seem to make the leap from playing great shows in smaller clubs to playing big rooms on bills that people are actually excited about. A few years of playing smaller rooms and your band should be ready to start making a name for itself. But toiling away in obscurity, waiting for someone to discover you isn’t a viable way to make it as a musician. And if you live in a hyper-competitive music market such as New York City (like I do), you really can’t just wait around.